The first weapon bomb.

The laboratory in Singapore, researchers are developing and breeding suicide bombers. If their efforts to materialize, they will be welcome, not in prison for their purposes no people or buildings. TheyBЂ ™ bacteria again. found a new way of killing Pseudomonas aeruginosa, opportunistic species that thrive where people are weak. It usually affects hospital patients whose immune system was hit. It is aimed at any fabric, it can get foothold in BЂ "light, blisters, ulcers BЂ" and it often leads to deadly infections. To find and destroy this threat, Saiedi and Wong used a common laboratory bacteria

Escherichia coli as a pawn. These E. coli recruits

produce protein LasR, which recognizes that the molecules AP

sticks cells use to communicate with each other. When LasR detect these chemical signals, it switches to the two genes. The first weapon bomb. It produces a pyocin, a toxin that kills

P. Sticks

by drilling through the outer wall and causing it to leak inside. The second gene bombs. It produces a protein that causes

E. coli to break apart, killing themselves, but also releasing a stream of deadly pyocin surrounding

P. sticks. The beauty of this solution is that it uses IP aeurginosa

BЂ ™ own weapons against him. Pyocins actually

P. Sticks

innovation. When the going gets tough times, these opportunists use pyocins kill competing strains. Saeidi and Wong focused on one of these weapons BЂ "pyocin known as S5. It consists of two parts: one doing the killing, the other makes a host cell immunity to his own weapon. In their armed bombers of pyocin S5, Saeidi and Wong found that they could kill a lot

P. Sticks

strains that cause problems for hospital patients. During previous laboratory tests, E. coli

bombers proved remarkably effective against P. sticks. When these two species were mixed together, the bombers got about 99% of their goals. They even killed some 90% of cells in the mucous community PA

sticks called biofilm. Biofilm is a bacterial bridge, and they are known to be difficult to destroy. E. coli

bombers align them. Of course, Saeidi and WongBЂ ™ s method is far from the actual clinical use. They havenBЂ ™ is not even tested its bacteria suicide bomber in live animals yet, much less in human patients. This is just proof of principle. However, itBЂ ™ hard not to admire the brilliant scientists are studying new ways to fight infectious bacteria. We eventually lose the war against these microorganisms. Development of new antibacterial drugs stopped. The vast majority of antibiotic classes were created between 1940 and 1960, and only two new entry in the last decade. Meanwhile, bacteria develop resistance to the current arsenal, and people have documented strains, which can not be known almost all of our products. P. coli is particularly difficult to treat because itBЂ ™ s have a natural resistance to a wide range of antibiotics. He has a number of molecular pumps that evict any drug that strattera side effects gets into it. Doctors often try to treat it by striking it with a number of different drugs, but it can access the sleeping and tolerant country, where he lives, keeping their heads. Meanwhile, the pressure of drugs harm beneficial bacteria that normally colonize our body. As an alternative, some researchers tried to use viruses called bacteriophages that target and kill bacteria. TheyBЂ ™ I had

but Saeidi and Wong believe that this approach has problems. It can be used only once BЂ "after the host made antibodies against the virus. Saeidi and Wong took a different approach. Their work is an example of an exciting field where scientists settings biology to perform tasks, their natural counterparts may not. Often it is associated with knitting together natural ingredients in new combinations, like picking parts off the shelf to create custom creatures. In this case Saeidi and Wong associated genetic components for recognition

P. sticks, forming pyocin and implementation of explosive suicide, so that the first event will cause the last two. Field generated more funny and more useful achievement, including the use of bacteria and fungi, to,,

well. But still no one was trying to send bacteria after its kind. Saeidi and WongBЂ ™ cabinet may be preliminary, but they burned a fresh and intriguing track. Help: Saeidi, Wong here, Nguyen, Ling, Leong, Bo Zhang. In 2011. Engineering microbes to sense and eliminate

aeruginosa, pathogens of man. Molecular Biology Systems August 16, 2011

on in,,,,

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